Set amid San Francisco’s shopping, financial and museum districts, The St. Regis San Francisco is located at 125 Third Street (at Mission Street). The 40-story tower has 260 spacious guestrooms, which feel more like sophisticated city pied-à-terre than upscale crash pads. Built in 2005, the Five-Star hotel’s décor is sleek and contemporary. Both the concierge and the famed St. Regis butlers provide attentive service, making the luxury hotel popular with business and leisure travelers alike. The St. Regis is home to Remède spa and two restaurants, Ame and Vitrine. In a city as hilly as San Francisco, it’s nice to be situated away from its ups and downs.